• Fibroblast growth factor receptors FGFRs play an essential r

  2021-12-30

  

  Fibroblast growth factor receptors (FGFRs) play an essential role in the regulation of cell survival, proliferation, migration and differentiation. FGFRs are a family of receptor tyrosine kinases (RTKs) exhibiting an extracellular immunoglobulin (Ig)-like ligand binding domain, a transmembrane domai

• It has been reported that aberrant GPR expressions

  2021-12-30

  

  It has been reported that aberrant GPR120 expressions were detected in colorectal carcinomas, compared with normal tissues. In addition, GPR120 stimulated cell motile activity and angiogenic property in colon cancer cells [10]. Recently, we indicated that GPR40 suppressed cell motile and invasive ac

• Here we report a new human genetic disorder in

  2021-12-30

  

  Here, we report a new human genetic disorder in a patient with hypoalgesia, altered fear and memory symptoms, and a non-anxious disposition. This disorder is attributable to co-inheritance of a microdeletion in a novel pseudogene and a known FAAH hypomorphic SNP. The microdeletion is flanked by repe

• The proposed contributory role of

  2021-12-30

  

  The proposed contributory role of endogenous histamine via activation of H1 receptor in the locomotor sensitization induced by caffeine was further ratified by H1 receptor antagonism during the induction phase and subsequently its effect on expression to locomotor sensitization induced by caffeine.

• Moreover we have demonstrated that

  2021-12-30

  

  Moreover, we have demonstrated that internalization and subcellular trafficking of NPRA, using IF staining (IFS) and co-IP of plasma membrane, endosomal, lysosomal, and recycling endosome markers to follow intracellular trafficking and signaling by confocal IF microscopy (CIF) and immunoblotting (IB

• Nitrosylation mediated post translational modifications

  2021-12-30

  

  Nitrosylation-mediated post-translational modifications of proteins through GSNOR play critical roles in modulating plant defense responses to diverse abiotic and biotic stresses (Frungillo et al., 2013, Leterrier 2011). As the most fundamental and intricate physiological process of plants, photosyn

• In conclusion this is the first description of a

  2021-12-30

  

  In conclusion, this is the first description of a GPR81 agonist with an ability to exert in vivo efficacy without causing flushing. These results demonstrate that GPR81 small-molecule agonists may be effective for treating dyslipidemia. In addition, targeting GPR81 could prevent the unwanted side ef

• br Acknowledgments br Free fatty acids

  2021-12-30

  

  Acknowledgments Free fatty acids (FFAs) are not only essential nutritional components, but they also function as signaling molecules. Recently, a G protein-coupled receptor (GPCR) de-orphanizing strategy successfully identified multiple receptors for FFAs, which function on the cell surface and

• Introduction The brain contains abundant fatty acids

  2021-12-30

  

  Introduction The brain contains abundant fatty acids, which serve as constituents of membranes and as an energy source. In addition, fatty acids and their metabolites contribute to signal transduction between neurons or neurons and glial cells, suggesting that fatty acids play a crucial role in dev

• The neurobiological mechanisms underlying DHK induced

  2021-12-30

  

  The neurobiological mechanisms underlying DHK-induced NOR learning and memory impairments remain unclear. Accumulated evidence shows that astrocyte-neuron lactate shuttle is of crucial important in synaptic plasticity and memory formation, and regulation of neuronal gene expression related to synapt

• br Conflict of interest br Introduction Since

  2021-12-30

  

  Conflict of interest Introduction Since its discovery in 1958 [1]the Ca2+-dependent K+ efflux in human red blood SYBR Safe DNA Gel Stain (RBC) (further referred to as the Gárdos effect) has been extensively studied (see 2, 3for review) and has been helpful in understanding the role of the Ca2

• br Conclusion In the present study we

  2021-12-29

  

  Conclusion In the present study, we found that the majority of commercially available antibodies and antibody-based tools against galanin and its receptors that we tested do not meet validation requirements. Therefore, critical validation of these tools by the user is essential before being used

• Receptor tyrosine kinases RTKs consist of subfamilies in hum

  2021-12-29

  

  Receptor tyrosine kinases (RTKs) consist of 20 subfamilies in humans, all of which share a common structure consisting of extracellular ligand-binding region, a single-pass transmembrane domain and an intracellular tyrosine kinase domain [2]. Binding of a growth factor to the ligand-binding domain r

• br Materials and methods br Results br

  2021-12-29

  

  Materials and methods Results Discussion ERK5 signaling and its regulation has gained focus in recent years specially in the subject of cardiovascular biology, where this kinase plays a key role in angiogenesis and maintenance of blood vessel integrity [18,20,34,35]. The signaling pathways

• Our present data together with other studies have shown that

  2021-12-29

  

  Our present data together with other studies have shown that the communication of stroma and cancer cells via ECM-cell interaction led to the primary activation of FAK [41]. Here we propose a model depicting an important role of ADAM12-L in the regulation of ESCC invasion and metastasis. ADAM12-L ov

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