• Interestingly some drugs have been shown

  2021-06-17

  

  Interestingly, some drugs have been shown to be effective in the regulation of cytokine production (such as IL-2, IL-10, IL-27, IL-35, IL-37 and transforming growth factor-β, TGF-β) and, therefore, having a key role in the management of certain inflammatory-based clinical conditions (Banchereau et a

• It is now widely known that blockade of CysLT

  2021-06-17

  

  It is now widely known that blockade of CysLT1 receptors strongly inhibits antigen-induced bronchial contractions in specimens isolated from non-asthma subjects. However, this blockade is not complete as shown in the present study and in other literature.4, 15, 16 The results of the current study su

• As discussed in the introduction many pregnant

  2021-06-17

  

  As discussed in the introduction, many pregnant women take medications such as nifedipine and indinavir, which are considerably metabolized by CYP3A [26]. Previous reports have also shown increased CYP3A activity following pregnancy [7], [9], which is consistent with our results. However, previous s

• Ung et al examined a variety of structural

  2021-06-17

  

  Ung et al. examined a variety of structural features based upon the location of the DFG-motif and the αC-helix to define the conformational space of the catalytic domain of protein kinases [75]. They reported that the DFG motif can move from its active DFG-Din location to the inactive DFG-Dout locat

• In the present study we identified that SDF could significan

  2021-06-17

  

  In the present study, we identified that SDF-1α could significantly elevate the expression of p-P65 in the NF-κB signaling pathway and p-Akt in the PI3K-Akt signaling pathway, while significantly reducing the expression of p-IκB in the NF-κB signaling pathway. AMD3100 and hesperidin antagonized the

• Pahlavanzadeh and Fakouri Baygi employed

  2021-06-17

  

  Pahlavanzadeh and Fakouri-Baygi [6] employed PC-SAFT EoS to predict the pdgfr inhibitor of carbon dioxide by aqueous MEA solutions. They used the ideal form of Smith–Missen algorithm to calculate liquid phase concentrations. The results illustrate acceptable accuracies so that the AAD was achieved

• br User knowledge representation Various representation appr

  2021-06-17

  

  User knowledge representation Various representation approaches of user interests and preferences are proposed. In this work, we advocate a multidimensional semantic approach based on Bouzghoub et al. meta-model (Bouzeghoub and Kostadinov, 2005), depicted in Fig. 6, to model the user profile. The

• Water inorganic salts sugars lipids nucleic acids and

  2021-06-17

  

  Water, inorganic salts, sugars, lipids, nucleic acids and proteins are the main basic materials forming the organism. Life activities can be controlled or regulated by a series of complicated and chain-reactive protein–protein interactions. Protein–protein interaction is considered as the bases and

• br Acknowledgements This work was

  2021-06-17

  

  Acknowledgements This work was supported by National Natural Science Foundation of China (31701807, 31572000) and Jiangsu Province Science Foundation for Youths (BK20170491). Introduction Two Cl− channels of the ClC family, ClC-K1 and ClC-K2 (or their human orthologs ClC-Ka and ClC-Kb, respec

• Gamboge is a dry resin obtained

  2021-06-17

  

  Gamboge is a dry resin obtained from Garcinia hanburyi HOOK. f. (Guttiferae). It has a variety of bioactivities, including detoxifying, homeostasis maintaining, anti-inflammatory and parasiticidic effects. Available evidence suggests that gamboge bears anticancer characteristics with gambogenic lpl

• Currently phosphodiesterase type PDE inhibitors

  2021-06-17

  

  Currently, phosphodiesterase type 5 (PDE-5) inhibitors are used widely as the first- line oral treatment for erectile dysfunction of varying causes. Radical prostatectomy for the treatment of prostate cancer is frequently associated with erectile dysfunction, and this type of erectile dysfunction is

• In the literature we can find two different

  2021-06-17

  

  In the literature, we can find two different modes of action for estrogens: Firstly there is the commonly accepted genomic pathway. Estrogens pass the cell membrane due to their lipophilic character via diffusion and bind to estrogen receptors (ERs) in the cytoplasm. After binding a dimerization of

• The authors then showed that Spt interacts

  2021-06-17

  

  The authors then showed that Spt6 interacts directly with the PRC2 subunit Suz12. This interaction occurs in solution but not on chromatin, suggesting that Spt6 may prevent PRC2 recruitment by binding to Suz12. They then mapped the domains in both Spt6 and Suz12 that are involved in this interaction

• The present study also showed that

  2021-06-17

  

  The present study also showed that EP2 deficiency and EP4 antagonism significantly suppressed psoriatic PyBOP in an imiquimod model. Notably, however, the combined EP2 deficiency and EP4 antagonism did not completely suppress ear swelling in this model, possibly because there is the IL-17–independe

• br Methods br Results br Discussion To our knowledge

  2021-06-16

  

  Methods Results Discussion To our knowledge, this is the first report to investigate the association between DBH genotype and pDβH activity in Han Chinese subjects. We also examined the relationship among DBH gene polymorphisms, pDβH activity and cognitive function in patients with schizoph

15719 records 615/1048 page Previous Next First page 上5页 611612613614615 下5页 Last page