• Routine administration of exogenous GC is

  2020-08-03

  

  Routine administration of exogenous GC is pertinent during late gestation, particularly in women who are at risk of delivering a preterm infant, aiming at ensuring proper neonatal outcome and survival (Kamath-Rayne et al., 2012). Unfortunately, despite its beneficial roles in foetal survival, variou

• br Acknowledgements This work was supported

  2020-08-03

  

  Acknowledgements This work was supported by the National Natural Science Foundation of China (31572039), the National Program on Key Basic Research Projects (973 Program, 2013CB127600) and China Postdoctoral Science Foundation (2016M601946). Introduction Parkinson\'s disease (PD) is a neurolo

• br Experimental procedure br Results and

  2020-08-03

  

  Experimental procedure Results and discussions Lombardi plate cohesion, mini slump flow diameter and marsh cone flow time of grout samples are shown in Table 2. Moreover the rheological properties including plastic viscosity and yield stress of grout samples are listed in Table 3. The correlat

• In recent years the industrial applications

  2020-08-03

  

  In recent years, the industrial applications of enzymes have exploded. Compared with conventional procedures based on acid-base and high temperature, enzymatic hydrolysis offers high efficiency and specificity. In addition, enzymatic reactions can be carried out under milder conditions with less pol

• The binding of collagen X to DDR

  2020-08-03

  

  The binding of collagen X to DDR2 differs from the binding of collagen X to α2β1 integrin in that the triple helical conformation is essential for DDR2 binding. We previously reported that heat denatured pepsinised collagen X supported cell adhesion via α2β1, indicating that the triple-helical confo

• In summary the novel oxadiazole DGAT inhibitor

  2020-08-03

  

  In summary, the novel oxadiazole DGAT-1 inhibitor was identified and SAR exploitation enabled a design strategy to improve both potency and LLE leading to the clinical candidate , which displayed good pharmacokinetics and demonstrated in vivo efficacy in obesity related models. Results from the fur

• Specific modulation of the effects of

  2020-08-03

  

  Specific modulation of the effects of leukotrienes is possible by intervention of the biosynthesis or by blocking the specific leukotriene receptors. Three types of leukotriene receptors have been identified in humans: BLT, CysLT1, and CysLT2. The CysLT1 receptor, formerly LTD4, has been most thorou

• Compound proved to be only weakly active

  2020-07-31

  

  Compound proved to be only weakly active as an antagonist of CRTh2, with binding affinity () of approximately 9.2μM (). Incorporation of various substituents at the 5-position () improved affinity by 2–3-fold. Incorporation of methyl at the 2-position () also increased binding by threefold. The eff

• Various domains of DDR have been shown to be important

  2020-07-31

  

  Various domains of DDR1 have been shown to be important for receptor clustering and its oligomeric status. It is now understood that (i) dimerization [7] and higher-order oligomerization [12], [18] of the DDR1 extracellular domain (ECD) enhance its binding to collagen; (ii) DDR1 exists as non-covale

• We also extended our observations

  2020-07-31

  

  We also extended our observations with Ube2E1 to other members of Ube2E class of E2s to show that self-ubiquitination-mediated activity attenuation is preserved across the Ube2E family. Sequence analysis revealed that this 89 25 preservation is a consequence of perfectly conserved lysines in the N-

• Paprotrain The reduced DNA stability at RH confirms previous

  2020-07-31

  

  The reduced DNA stability at 100% RH confirms previous results for incubates at these conditions, although in the present study amplifiable DNA still survived for months. The crucial point appears to be the onset of microbial growth, which happened at room temperature and at 35 °C. In the biological

• br Acknowledgments This work was

  2020-07-31

  

  Acknowledgments This work was financially supported through grantsfrom National Natural Science Foundation of China (No. 21402105), and Shenzhen Municipal government SZSITIC (JCYJ20160301153753269). Introduction Due to their unique physical, electrical, and optical properties, ultrasmall fluo

• br Materials and methods br

  2020-07-31

  

  Materials and methods Results Discussion We have previously shown that CK2 downregulation induces premature senescence in IMR-90, HCT116, and MCF-7 cells [17,[19], [20], [21]], and enhances expression of age-related biomarkers and shortens lifespan in nematodes [18]. Because SAHF are formed

• br Experimental br Results and discussion br Conclusions In

  2020-07-30

  

  Experimental Results and discussion Conclusions In this work we presented the direct electrochemical behaviour of the Mo containing formate dehydrogenase, purified from D. desulfuricans, where the Mo centre redox features were observed. The results allowed to calculate the reduction potenti

• It is well established that Shp

  2020-07-30

  

  It is well established that Shp-2 can function as a substrate for several RTK, such as PDGF or EGFR [23], [36]. To test whether DDR1 recognizes Shp-2 as its substrate, we overexpressed a catalytically inactive Shp-2 mutant together with DDR1b in 293 cells [31]. Immunoprecipitation of Shp-2 followed

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