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LYL belongs to the basic
2019-04-28
LYL1 belongs to the basic helix-loop-helix (bHLH) transcription factor family, which plays important roles in a variety of developmental processes, including hematopoiesis [6]. The biological function of LYL1 is largely unknown, but its expression is restricted to hematopoietic cells, including myel
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Evidence supporting the benefit of dexrazoxane
2019-04-28
Evidence supporting the benefit of dexrazoxane as cardioprotective therapy in adults with acute leukemia are scant [11]. However, there is a significant need for cardioprotective therapy, particularly in older individuals with preexisting cardiovascular disorders and/or prior anthracycline exposure,
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The OptiVol Fluid Index OVFI which is derived
2019-04-26
The OptiVol Fluid Index (OVFI), which is derived from changes in intrathoracic impedance, can effectively assess HF by analyzing the changes in the intrathoracic impedance detected by the original OptiVol algorithm. Small et al. previously determined that a frequent and extended threshold crossing A
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In our study we observed that MT produced a improvement
2019-04-26
In our study we observed that MT produced a 50% improvement in the % area of tissues covered over that of H&E. It is possible that its three-in-one (trichrome) combination of dyes may be responsible for the large % area covered and high intensity measurement. This is in line with the report of Stree
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The presence of an inflammatory infiltrate is associated wit
2019-04-26
The presence of an inflammatory infiltrate is associated with poor prognosis in a number of malignancies, including those with a predilection for metastasis to bone. CAFs are capable of promoting, and maintaining an inflammatory environment by recruiting immune cells; in particular monocyte/macropha
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By GBD region in the past two decades
2019-04-26
By GBD region, in the past two decades, the largest increases in incidence of ischaemic stroke were in eastern Europe, central and east Asia, north and sub-Saharan Africa, and the Middle East (figure 1), with the largest increase (22%) noted in the Democratic Republic of Congo. Notably, some of the
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br VIII Si atendemos a que Pablo del
2019-04-26
VIII. Si atendemos caspase inhibitor que Pablo del Prado en su Directorio espiritual, todavía en el año de 1650, incorporaba numerosas oraciones para la comunión espiritual indígena, junto a recomendaciones sobre la exclusión de la efectiva, no parece probable que se alcanzara nunca una normaliza
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Although the NCCN IPI is a promising simple
2019-04-26
Although the NCCN-IPI is a promising simple scale based on conventional clinical factors, its usefulness remains controversial [6,7]. It should be evaluated in populations of different regions and ethnicities before adopting it for routine clinical use. Conflict of interest Report At presenta
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During a mean of months
2019-04-26
During a mean of 41±29 months of follow-up, freedom from VT or VF was observed more frequently in the non-inducible group (24 of 30 (75%)) than in the inducible group (9 of 21 (43%), P=0.03). The estimated cumulative freedom from VT or VF was 88%, 83%, 75%, and 55% at the 1-, 2-, 3-, and 5-year foll
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Esta subalternidad por ende no tiene referente estable pero
2019-04-25
Esta subalternidad, por ende, no tiene referente estable pero tampoco es una abstracción relativa, de manera que los grupos reprimidos históricamente, entre ellos ciertas razas, proveen ejemplos ineludibles pero no exentos de su propio exceso. De manera que todo planteamiento anclado en la identidad
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The PAX gene encodes a transcriptional
2019-04-25
The PAX5 gene encodes a transcriptional factor, which is specifically expressed at the early stages of B-cell differentiation and it is required for B-cell development. Its dysregulation is involved in the leukemogenesis of B-ALL. The PAX5 gene rearrangements account for approximately 2.5% of pedia
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br Inherited Arrhythmia Clinics br
2019-04-25
10. Inherited Arrhythmia Clinics The evaluation and treatment of GSK J4 suspected of having inherited arrhythmias requires a multidisciplinary team and approach. The presentation is often that of a proband or family member who has experienced a life-threatening arrhythmia, sudden cardiac arrest
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hsp90 inhibitor Heart failure is a complex disease
2019-04-25
Heart failure is a complex disease and the status of each patient is highly heterogeneous; therefore, nominal manufacturer-delivered device settings may not be optimal for all patients who receive CRT implantation. A growing body of evidence suggests hemodynamic and clinical status benefits associat
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Introduction Atrial fibrillation AF is a common cardiac arrh
2019-04-25
Introduction Atrial fibrillation (AF) is a common cardiac arrhythmia that becomes more prevalent with age [1] and is associated with an increased long-term risk of stroke, buy UM 171 failure, and all-cause mortality [2]. Since Einthoven recorded the electrograms in 1906 [3], AF has widely been rec
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In February a left neck infiltrating
2019-04-25
In February 2013, a left neck infiltrating purpuric lesion around a previous surgical scar (lymph node biopsy) with mild pain was noted. A subsequent skin biopsy revealed metastatic adenocarcinoma, compatible with ampulla of Vater primary, thereby confirming disease progression with skin metastasis.
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