• The combination of romidepsin and bryostatin has been

  2018-11-09

  

  The combination of romidepsin and bryostatin-1 has been shown to be one of the best inducers of latent HIV-1 in primary CD4+ T CFM 4 (Laird et al., 2015). However, bryostatin-1 has been showed to be involved in the modulation of NFkB and NFAT (Williams et al., 2004) and romidepsin is known to affe

• br Materials and methods br Results br

  2018-11-09

  

  Materials and methods Results Discussion In the search for drugs for human prion diseases, we conducted docking simulation using a DEGIMA supercomputer. Results from the in vitro and ex vivo drug screening revealed that NPR-053 and -056 significantly reduced PrPSc levels (Figs. 2 and 5). Al

• rac protein br Methods br Results br Discussion The

  2018-11-09

  

  Methods Results Discussion The intriguing relationship between commensal microbes and atherosclerosis has received increasing attention over the past few years. However, the specific mechanisms whereby commensal microbes regulate the development of atherosclerosis are just beginning to be e

• At birth infants already have incipient abilities for audito

  2018-11-09

  

  At birth, infants already have incipient abilities for auditory localization (Morrongiello and Clifton, 1984) and for segregating concurrent sound streams leading to the identification of objects in the environment (Winkler et al., 2003). The origins of these abilities can be traced back to prenatal

• br A brain MRI template provides

  2018-11-09

  

  A fda approved MRI template provides a standard reference for assessment of brain structure and function (). Advances in understanding of the structure, function, and development of human brain would be facilitated with the availability of population-specific MRI templates in neuroimaging researc

• br Adolescence developmentally meaningful indicators As

  2018-11-09

  

  Adolescence (developmentally meaningful indicators) As noted several times above, general aspects of precision can be especially complex in the field due to our target population. Adolescence is a particularly long phase of development, spanning nearly a decade or more depending on whether one in

• br Conflict of interest br Introduction br

  2018-11-09

  

  Conflict of interest Introduction Methods Results Within the OSAHS group, d was significantly lower in the afternoon 1.705±0.033 than the morning 1.737±0.042 (Fig. 1) (p Discussion This is the first study to investigate dynamically and quantify the arrangement and mechanical properties

• Under light dark cycles all tuco tucos displayed very

  2018-11-09

  

  Under light/dark cycles, all tuco-tucos displayed very robust 24h rhythms, with wheel-running activity concentrated in the dark phase (Fig. 1A). An unusual event of rhythm disruption was registered in several individuals: On October 22th 2008, one of the females (captured in July of the same year) g

• br Introduction Immunosensors are a specific type of biosens

  2018-11-09

  

  Introduction Immunosensors are a specific type of biosensors and can be defined as compact analytical devices that yield measurable signals in response to specific antibody–antigen interactions. A large number of immunosensors have been developed using different kinds of transducers that exploit

• Las construcciones de carreteras transandinas unir

  2018-11-09

  

  Las construcciones de carreteras transandinas unirían partes apartadas y olvidadas de Perú, Bolivia y Colombia. La carretera interoceánica que une el estado brasileño de Rondonia con el departamento boliviano del Beni, constituyen los ejes andino y amazónico. Finalmente está la modernización de la v

• br Estudio en dos etapas El estudio para probar la

  2018-11-09

  

  Estudio en dos etapas El estudio para probar la hipótesis planteada sobre la relación inversa entre las transferencias y la eficiencia relativa en los municipios jaliscienses durante los años 1990, 2000 y 2010 es presentado en dos etapas. En la primera etapa, los municipios seleccionados anterior

• Second there are several studies that aimed to estimate

  2018-11-09

  

  Second, there are several studies that aimed to estimate the causal impact of the conditional cash transfer programs on adult labor supply in Brazil (e.g., Soares et al., 2007; Ferro and Nicollela, 2007; Tavares, 2008; Teixeira, 2008; Covre et al., 2008; Foguel and de Barros, 2008). These studies us

• March marked Multiple Sclerosis MS

  2018-11-09

  

  March 2–8 marked Multiple Sclerosis (MS) Awareness Week in the United States MS is a chronic, often debilitating disease of the central GDC0068 (CNS), affecting more than 2 million people worldwide. As recently as 25years ago, a diagnosis of MS came with no hope for course-altering treatment option

• br Acknowledgments br Introduction Sarcoidosis

  2018-11-09

  

  Acknowledgments Introduction Sarcoidosis is an inflammatory granulomatous disease of unknown etiology affecting multiple organs, such as the lungs, skin, CNS, and eyes (Costabel, 2001; Costabel and Hunninghake, 1999; Iannuzzi et al., 2007; Hunninghake et al., 1999). Common features shared by p

• In this issue of Jabbari et

  2018-11-09

  

  In this issue of , Jabbari et al. followed up on hair growth observed in a patient under baricitinib therapy, also a JAK1/2 inhibitor and studied JAK inhibitor action in the C3H/HeJ graft-recipient mouse model of AA (). Under JAK inhibitor treatment, CD8+ cell infiltrates and MHC class I and II expr

14991 records 979/1000 page Previous Next First page 上5页 976977978979980 下5页 Last page