• The ongoing efforts to identify targeted therapy for dediffe

  2018-11-07

  

  The ongoing efforts to identify targeted therapy for dedifferentiated, metastatic PTC has led to empirically driven clinical trials of different tyrosine kinase receptor inhibitors that disrupt MEK, VEGFR, FGFR and other signaling pathways. These therapies were intended to slow disease progression,

• We have long been searching for chemicals that could

  2018-11-07

  

  We have long been searching for chemicals that could prevent such cell death in vivo. For this purpose, we have hypothesized that such chemicals would maintain cellular ATP levels under these pathological conditions. In order to address this hypothesis, we developed KUSs as specific inhibitors of th

• It is known that evidence generated from small sample

  2018-11-07

  

  It is known that evidence generated from small sample sizes is especially prone to error: both false negatives due to inadequate power and false positives due to biased samples (Button et al., 2013). Meta- and mega-analysis of VBM studies combining data from independent studies can substantially imp

• br Materials and methods br

  2018-11-07

  

  Materials and methods Data availability The mass spectrometry datasets are publicly available from ProteomeXchange Consortium via the PRIDE partner repository (http://www.proteomexchange.org) with the dataset identifiers PXD001224 (GeLC–MSMS data) and PXD001088 (LC–MSMS data). Results obtained

• mtor pathway br Acknowledgments LM was supported by a Grant

  2018-11-07

  

  Acknowledgments LM was supported by a Grant (SFRH/BD/64592/2009) from the Fundação para a Ciência e Tecnologia IP (FCT)/POPH/FSE, Portugal. Data Transposable elements have been a critical part of the eukaryotic genome perhaps since their very beginnings. Millions of years of evolution have gi

• Fig shows the representative protein sequence identified wit

  2018-11-07

  

  Fig. 2 shows the representative protein sequence identified with confidence interval ≥95% in the study. (A) Protein sequence with identified peptide sequences highlighted in green. (B) Table with details of identified peptides. (C) MS/MS spectrum of the identified peptide MANQANIPVITLDR. (D) Assignm

• br Specification table br Value of the data br Data

  2018-11-07

  

  Specification table Value of the data Data Data on comparative antimycobacterial activity of total hydroethanolic extracts derived from five medicinal plant species is presented (Table 1). Data on in vitro cytotoxic activity of tested plant species and positive control drugs, isoniazid, rif

• Of particular relevance here is the notion of illusory recov

  2018-11-07

  

  Of particular relevance here is the notion of “illusory recovery” (Scarborough and Dobrich, 1990), which suggests that although LTs may catch up in some language areas, their underlying language impairment results in weaknesses in other aspects of language learning later in their development. Anothe

• The almost exclusive use of cardiac based measures of

  2018-11-07

  

  The almost exclusive use of cardiac-based measures of interoception reflects what is often an implicit assumption in the literature − that interoceptive sensitivity represents a unitary construct. It is assumed that those who exhibit a great deal of perceptual sensitivity for their heart rate will a

• br Materials and methods br

  2018-11-07

  

  Materials and methods Results Discussion To our knowledge, this is the first study to conduct a voxel-level investigation of the relationship between cerebellar GM and specific cognitive skills in a typically-developing pediatric population. The results support the OTX-015 that cerebellar

• The first group of sculptures

  2018-11-06

  

  The first group of sculptures to be displayed in the new Hall consisted of the awesome marbles of the Temple of Apollo Sosianus. Today, three beautiful columns of the Temple, which are placed on their podium and surmounted by the corner of the entablature, have been recomposed and are placed next to

• Unfortunately ICHs in different locations were found

  2018-11-06

  

  Unfortunately, ICHs in different locations were found to increase in the following vesicular monoamine transporter CT performed on August 21 (Fig. 2C) and August 28 (Fig. 2D). Systemic coagulopathy was excluded as the cause of ICH progression on account of normal coagulation function and platelet c

• br Acknowledgement br Introduction Murraya paniculata

  2018-11-06

  

  Acknowledgement Introduction Murraya paniculata (L.) belongs to the Rutaceae family. This plant is native to areas in Southeast Asia [1], such as Southern China, Vietnam and Malay Peninsula. In China, the ornamental plant M. paniculata is widely cultivated on the sides of the road for decorati

• br Fortification with seed oil containing unsaturated fatty

  2018-11-06

  

  Fortification with seed oil containing unsaturated fatty acids and phytosterols Plant sterols compromise a group of compounds which is the focus of research at the moment. They decrease cholesterol Spadin manufacturer and may thus protect against atherosclerosis [74,75]. Furthermore, they may ha

• Introduction Alzheimer s disease AD is a chronic

  2018-11-06

  

  Introduction Alzheimer’s disease (AD) is a chronic neurodegenerative disease and the most common cause of dementia, accounting for over 50% of individuals affected [1]. This disease is characterized by progressive memory impairment and cognitive decline interfering with daily life activities. The m

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