• A main strategy of regenerative medicine is the construction

  2018-10-29

  

  A main strategy of regenerative medicine is the construction of a biocompatible scaffold that, in combination with living prostaglandin synthase and/or bioactive molecules, replaces, regenerates or repairs damaged cells or tissue (Perán et al., 2012; López-Ruiz et al., 2012). Growth factors are com

• GFP expressing Rhesus nhpESC lines

  2018-10-29

  

  GFP-expressing Rhesus nhpESC lines (Table 1) used in the aggregation chimera assay produced expanded mouse blastocysts with GFP-expressing nhpESC lines 2706 and 3006 associated with the blastocyst inner cell mass (ICM) cells. We typically combined mouse zona pellucida-free 2-to-8-cell stage embryos

• In contrast to the above the loose cell network in

  2018-10-29

  

  In StemRegenin 1 cost to the above, the loose cell network in the +DAG group that was observed via histological staining may be a sign of reduced cell vitality. It is well known that cell death often leads to mineralization that is not combined with the formation of bone (Kirsch, 2006). Inorganic p

• br Disclosure statement br Acknowledgments We would

  2018-10-29

  

  Disclosure statement Acknowledgments We would like to express our sincere gratitude to our collaborators from Cellular Dynamics International Inc., especially to Susan DeLaura, Lucas Chase, Jeff Grinager, David Majewski and Monica Strathman for the support on the preparation of manuscript. We

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-29

  

  Experimental Procedures Author Contributions Acknowledgments Introduction In recent years, a number of small molecules have been identified that control stem cell differentiation and/or cell reprogramming. Surprisingly, only a few metabolites have been identified in this context, possibl

• Similar to our observation that

  2018-10-29

  

  Similar to our observation that Nanog−/− iPSCs could give rise to chimeric animals, Nanog null ESCs have been shown to contribute to the three germ layers (Chambers et al., 2007). However, in the case of ESC chimeras, Nanog−/− GFP+ crm1 were not detected in the germline after E12.5. Because the CAG

• br Materials and methods br

  2018-10-26

  

  Materials and methods Results Discussion The robust expression and purification of stable and biologically active eukaryotic proteins represent a bottleneck of protein transduction technology (Pan et al., 2010; Patsch & Edenhofer, 2007; Yang et al., 2011). In this study, we demonstrate reco

• The mdx mouse is a naturally

  2018-10-26

  

  The mdx mouse is a naturally-occurring genetic and biochemical homologue of DMD and has been widely used as an experimental model. Although mdx muscles retain their capacity to regenerate throughout life, certain muscle in old mdx mouse, including diaphragm (Stedman et al, 1991), soleus and plantari

• Paradoxically we found that mutant K Ras increases prolifera

  2018-10-26

  

  Paradoxically, we found that mutant K-Ras increases proliferation of quiescent intestinal stem p-Cresyl sulfate (Fig. 2), but also increases repair following damage (Fig. 3). This phenomenon is similar to the role that oncogenic N-Ras plays in hematopoietic stem cells (HSCs) (Li et al., 2013). In t

• There were discrepancies between the

  2018-10-26

  

  There were discrepancies between the mRNA and protein levels of p63 and K12. It is known that the mRNA level does not always correlate with the protein level. In addition, protein expression rather than mRNA expression dictates the phenotype of the cells. A better correlation was found between the c

• Although RA is sufficient to promote

  2018-10-26

  

  Although RA is sufficient to promote the development of spermatogenic read more here from mSSCs to spermatocytes, the Sertoli cell co-culture increases further the induction efficiency. Severe apoptosis of the germ cells were observed under both the feeder-free and the co-culture conditions, indica

• br Introduction Embryonic stem cells

  2018-10-26

  

  Introduction Embryonic stem cells (ESCs) are self-renewing pluripotent cells, derived from the inner cell mass of apoptosis pathway (Smith, 2001). The transcriptional control of pluripotency is well characterized. Master transcription factors, such as Pou5f1 (Oct4), Sox2, and Nanog, maintain plu

• In examining why African American patients of midwifery care

  2018-10-26

  

  In examining why African American patients of midwifery care had lower prevalence of adverse infant birth outcomes in two of these studies, it is important to assess the significance of “race”. Nancy Krieger defines race/ethnicity as “a social, not biological, category, referring to social groups, o

• Table shows results from models partitioned by sex

  2018-10-26

  

  Table 4 shows results from models partitioned by sex. In Blebbistatin to the pooled results, Model 2 of Table 4, our fully adjusted model, shows no statistically significant difference in the probability of being a current smoker among the first generation males in the sample by age at migration. T

• br Definition of local product Thilmany

  2018-10-26

  

  Definition of local product Thilmany et al. (2008) suggested that the importance of the ‘local food’ movement was manifested by the selection of ‘Locavores’ in 2007 as the word of the year by the New Oxford American Dictionary, which defines the term as a resident who tries to consume food produc

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