• ABT-199 (Venetoclax): Leveraging Bcl-2 Selective Inhibiti...

  2025-09-23

  Explore the application of ABT-199 (Venetoclax), a potent Bcl-2 selective inhibitor, in dissecting mitochondrial apoptosis pathways and Bcl-2 mediated cell survival. This article highlights recent mechanistic insights and practical guidance for advanced apoptosis research in hematologic malignancies.

• EZ Cap™ Firefly Luciferase mRNA: Enhancing Bioluminescent...

  2025-09-22

  Explore how EZ Cap™ Firefly Luciferase mRNA with Cap 1 structure advances bioluminescent reporter assays, mRNA delivery, and translation efficiency. This article examines the molecular advantages of capped mRNA for enhanced transcription efficiency and its utility in complex in vitro and in vivo research models.

• Filipin III: Precision Cholesterol Mapping in Liver Disea...

  2025-09-19

  Explore how Filipin III, a cholesterol-binding fluorescent antibiotic, enables high-resolution visualization of membrane cholesterol in liver disease models. This article details Filipin III’s application in cholesterol detection within membranes and its critical role in unraveling mechanisms of cholesterol homeostasis in metabolic dysfunction-associated steatotic liver disease (MASLD).

• ARCA EGFP mRNA (5-moUTP): Practical Strategies for Enhanc...

  2025-09-18

  This article explores the advanced features of ARCA EGFP mRNA (5-moUTP), focusing on its utility as a direct-detection reporter mRNA for fluorescence-based transfection in mammalian cells. Emphasis is placed on the molecular design for innate immune activation suppression and practical storage considerations for ensuring mRNA stability enhancement.

• Notably we have characterized the mechanism of

  2025-03-03

  

  Notably, we have characterized the mechanism of action of ALK in the context of our current understanding of NLRP3 activation [5]. Non-priming macrophages, including BMDMs, exhibit no or minimal activation of NLRP3 in response to ATP. In contrast, LPS priming of macrophages makes them highly suscept

• In our previous study we

  2025-03-03

  

  In our previous study we found that the total activity of aldehyde dehydrogenase in cancer ACK lysis buffer of RCC is at the same level as in normal renal tissue [10]. These findings are similar to our results in serum patients with renal cancer. There is no significant difference between ALDH acti

• With one exception all receptors for dopamine DA serotonin h

  2025-03-03

  

  With one exception, all receptors for dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT), and norepinephrine are metabotropic receptors. The five metabotropic DA receptors (D1–D5) in the CNS are involved in motivation, pleasure, cognition, learning, memory, fine motor control, and modulate neuroen

• br There is evidence to suggest that GMF activities are

  2025-03-03

  

  There is evidence to suggest that GMF activities are regulated in vivo by post-translational modification. indeed, there is strong precedent for ADF-homology family proteins being regulated in this manner. Cofilin is inhibited by phosphorylation of a serine residue at its N terminus. This residue

• Additionally in a previous transgenic model

  2025-03-03

  

  Additionally, in a previous transgenic model with autotaxin under the control of the MMTV-LTR promoter, aberrant expression of human autotaxin caused late-onset, metastatic breast cancer [5]. The AT-ATX transgenic model is analogous to the previous one because ∼30% of all spontaneous tumors appeared

• br Acknowledgement This work was funded by NIH NINDS

  2025-03-03

  

  Acknowledgement This work was funded by NIH/NINDS grant number NS080967 to C. Waites. Introduction Macro-autophagy also called autophagy is a conserved pathway for the lysosomal degradation and recycling of intracellular materials. It is instrumental for the homeostasis of cells and tissues a

• Maduramicin is a polyether ionophore antibiotic that

  2025-03-01

  

  Maduramicin is a polyether ionophore antibiotic that has the smallest margin of safety between the maximum authorized dosage and the minimum toxic concentration. Clinical signs of maduramicin intoxication are similar to that of other ionophores, often causing feed refusal, anorexia, respiratory dist

• To introduce in a simple

  2025-03-01

  

  To introduce in a simple way the variability in the concentration of the proteins involved in the process, and to consider possible stochastic effects due to possible finite sizes of the populations involved in the problem, the dynamics of each cell is studied using the Gillespie’s algorithm (Gilles

• Riluzole br Antiangiogenic therapy in non

  2025-03-01

  

  Antiangiogenic therapy in non-small cell lung cancer (NSCLC) Antiangiogenic targeted therapy is an area of active research in which numerous agents have been studied and have been shown to be effective for many tumor types including NSCLC. Angiogenesis is frequently upregulated in malignant solid

• ATPase activity blocker Finally microRNAs miRNA seem to play

  2025-03-01

  

  Finally, microRNAs (miRNA) seem to play an important role in AR signaling in BC. Some authors have described a differential ATPase activity blocker of miRNAs in AR-positive BCs compared to AR-negative ones. VEGF and mTOR pathways were also reported as implicated in miRNA dysregulation, suggesting a

• br Materials and Methods br Author

  2025-03-01

  

  Materials and Methods Author Contributions Conflicts of Interest Acknowledgments We thank Francine Jodelka for technical assistance and Gopal Thinakaran for the CTM-1 antibody. This work was financially supported by RFUMS internal research funding and NIHS10 OD 010662. Introduction A

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