• Glucose uptake a critical metabolic control point in

  2021-09-14

  

  Glucose uptake, a critical metabolic control point in glycolysis, is mediated by the GLUT (SLC2) family of integral membrane transporters (Mueckler and Thorens, 2013). GLUT1 (SLC2A1), one of the most well-studied members of the SLC2 family, exhibits a wide tissue distribution; cell surface expressio

• However it is unclear whether the parent

  2021-09-14

  

  However, it is unclear whether the parent and transition metal substitution in Keggin-type phosphomolybdic 1625 australia will reveal the best effects on α-glucosidase. Therefore, the Keggin-type H3PMo12O40 (abbreviated as PMo12) and three transition metal-substituted POMs (Na4PMo11VO40, Na6PMo11Fe

• As early as glucagon was shown to increase

  2021-09-14

  

  As early as 1957, glucagon was shown to increase molarity of a solution expenditure in rodents in both pair-feeding studies and through directly increasing oxygen consumption [23], [24]. This has more recently been confirmed in man, through indirect calorimetry during glucagon infusions [25], [26],

• Medulloblastoma predominantly occurs in infants and

  2021-09-14

  

  Medulloblastoma predominantly occurs in infants and children, and is the most-common type of paediatric malignant Spautin-1 australia tumour, accounting for about 20% of all childhood brain tumors [63]. According to cancer genomics, medulloblastoma consists of at least 4 distinct subgroups: Hh drive

• br Materials and methods br Results br Discussion BTB as

  2021-09-14

  

  Materials and methods Results Discussion BTB, as a necessary structure for the spermatogenic epithelium, provides an important internal environmental for spermatogenesis and its disruption leads to male infertility (Qiu et al., 2016). GJs and TJs which are mainly components of BTB play esse

• Type II diabetes is characterized by an inability

  2021-09-14

  

  Type II diabetes is characterized by an inability to maintain glucose homeostasis due to insulin desensitization and/or insufficient insulin secretion. GPR40, also known as free fatty cholinesterase inhibitors receptor 1 (FFAR1), is a member of the G-protein-coupled lipid-activated family of recepto

• Considering the fact that NADPH oxidase is the main source

  2021-09-14

  

  Considering the fact that NADPH oxidase is the main source for paraquat and maneb-induced oxidative stress, we hypothesized that NADPH oxidase activation might contribute to dopaminergic neurodegeneration induced by paraquat and maneb through ferroptosis. To test our hypothesis, we investigated the

• The present study also demonstrated that edoxaban inhibited

  2021-09-14

  

  The present study also demonstrated that edoxaban inhibited both free and clot-bound FXa activity. The IC50 values for free and clot-bound FXa in this study are well consistent with Ki values for free FXa and FXa incorporated in prothrombinase complex (0.561 and 2.98nM, respectively) in our previous

• Here we report a new human genetic disorder in a

  2021-09-14

  

  Here, we report a new human genetic disorder in a patient with hypoalgesia, altered fear and memory symptoms, and a non-anxious disposition. This disorder is attributable to co-inheritance of a microdeletion in a novel pseudogene and a known FAAH hypomorphic SNP. The microdeletion is flanked by repe

• br Conflict of interest br

  2021-09-14

  

  Conflict of interest Acknowledgements This work was funded by the University of Turin (ex60% 2014), World Wide Style Project (WWS; University of Turin/Fondazione CRT) and University of Florence (ex60% 2014). ACR and AP designed the study; AP, EB and IO conducted the literature search and analy

• Thus both in Drosophila and mammals the Hippo

  2021-09-14

  

  Thus, both in Drosophila and mammals, the Hippo pathway responds to cell–cell junctions via an apical NF2/Mer-containing complex. Indeed, Hippo signalling and NF2 are required for contact inhibition of growth in cell culture, which is thought to reflect an in vivo function as a sensor of tissue crow

• br Heme oxygenase inhibitors Historically the first class of

  2021-09-14

  

  Heme oxygenase-1 inhibitors Historically, the first class of competitive HO-1 inhibitors was represented by MPs, heme analogs in which the central iron T16Ainh - A01 of heme is exchanged by another element, such as zinc, cobalt, tin, or chromium. These molecules compete with heme for binding to t

• Based on the molecular weights of glutamate g

  2021-09-14

  

  Based on the molecular weights of glutamate (147.13 g/mol) and MSG (169.111 g/mol), the amount of free glutamate intake obtained in this study was equivalent to 297 mg MSG/d and 370 mg MSG/d for children and adults, respectively. Several previous studies have assessed population intake of MSG from f

• GS967 Recently some published studies showed that HBV can in

  2021-09-13

  

  Recently, some published studies showed that HBV can induce autophagy in vitro and vivo [[19], [20], [21]]. The critical role of autophagy in HBV normal life cycle, such as HBV envelopment, has been gradually accepted by researchers from different laboratories [22,23]. HBV can trigger the autophagic

• br Acknowledgement br Introduction Malignant melanoma is an

  2021-09-13

  

  Acknowledgement Introduction Malignant melanoma is an aggressive and highly metastatic cancer. The incidence of malignant melanoma is increasing all over the world, and the population of patients with advanced melanoma is growing [1], [2]. Malignant melanoma is often resistant to conventional

15670 records 561/1045 page Previous Next First page 上5页 561562563564565 下5页 Last page