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The occurrence of three Ag NORs per metaphase and or
2021-03-25
The occurrence of three Ag-NORs per metaphase and/or a maximum of three nucleoli per nucleus in most of the varieties may be explained by chromosomal rearrangements or unequal crossing-over events that induce the deletion of the fourth active rDNA loci. Also, the chromosome pair that showed less int
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br Acknowledgements br Introductio http www apexbt com
2021-03-25
Acknowledgements Introduction TB is also widely prescribed as a stain to identify proteoglycans and glycosaminoglycans (GAGs) in agarose gel electrophoresis (Dietrich and Dietrich, 1976; Coulson-Thomas et al., 2015). In addition, as adjunct to a photodynamic antimicrobial chemotherapy assay, T
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DNA hypomethylation has been found in liver
2021-03-25
DNA hypomethylation has been found in liver tumor and other tumors of humans, such as laryngeal cancer, Copanlisib tumors, tongue squamous cell carcinoma and uterine leiomyomas [[20], [21], [22], [23], [24]]. Then, we mainly sought to confirm whether TCA could induce DNA hypomethylation in vitro an
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Next the BE obtained for the different complexes were
2021-03-25
Next, the BE obtained for the different complexes were evaluated. From the BE obtained from our MD simulations, a very good binder can be differentiated from a very weak binder (−11.85 kcal/mol for MTX vs. −6.74 and −3.61 kcal/mol for compounds 14b and 15c, respectively) but ligands with similar bin
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Kim et al reported for
2021-03-24
Kim et al. reported for bioactive compounds originating from the endemic species in Korea, the hexane and EtOAc fractions of the MeOH extracts from the roots of Dystaenia takeshimana (Nakai) Kitagawa (Umbelliferae) showed cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) dual inhibitory activity b
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A further quandary concerning rediscoveries
2021-03-24
A further quandary concerning rediscoveries arises in habitats modified and frequented by humans, where rediscovered species may occur through accidental or deliberate introductions (Metcalf et al., 2007) rather than having persisted despite adverse conditions. Confusion regarding origin could evoke
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br STAR Methods br Acknowledgments We thank members
2021-03-24
STAR★Methods Acknowledgments We thank members of R.L. lab and F. Schweisguth for critical reading of the manuscript. We are also grateful to F. Janody, M. Miura, C. Bökel, H.D. Ryoo, G. Jiménez, the Bloomington Drosophila Stock Center, the Drosophila Genetic Resource Center, the Vienna Drosoph
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Mammalian cells contain significant amounts of a relatively
2021-03-24
Mammalian cells contain significant amounts of a relatively lesser known enzyme that shows marked specifity for ether lipids containing AA and other 20–22 carbon fatty acids. This enzyme is called CoA-independent transacylase (CoA-IT), and transfers polyunsaturated moieties of 20–22 carbons, typical
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Epitope analyses of AT AA
2021-03-24
Epitope analyses of AT1-AA and ET-AA indicate that the Z VDVAD FMK of both autoantibodies are located at the second extracelluar loop of both receptors. The specific epitopes for both autoantibodies are similar to what was reported previously in a cohort of patients from Brazil [6] and for AT1-AA al
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Several studies on the collagen
2021-03-24
Several studies on the collagen receptor DDR1 have revealed a defined collagen signaling pathway that causes cell scattering and cadherin switching. As mentioned earlier, DDR AZD 0530 on collagens are distinct from integrin binding sites; therefore, the same collagen protein can bind to DDR and int
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br Discussion The biochemical separation of exonuclease acti
2021-03-24
Discussion The biochemical separation of exonuclease activity from DNA-PK dependent endonuclease activity reported in this manuscript is consistent with genetic separation of Artemis enzymatic activity. Mutations in the protein which result in disruption of endonuclease activity have no effect on
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Several in vivo human studies have produced conflicting resu
2021-03-24
Several in vivo human studies have produced conflicting results for evaluating the inhibition of OCs on the metabolism of CYP3A substrates. Balogh et al. [12] demonstrated an approximately 25% inhibition of CYP3A activities in vivo after the administration of an OC containing 30μg of ethinylestradio
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Opiate withdrawal promotes the activation of the corticotrop
2021-03-24
Opiate withdrawal promotes the activation of the corticotropin-releasing factor (CRF) system, a major coordinator of neuroendocrine and behavioral responses to stressors. For instance, early (8–48 h) morphine withdrawal is associated with increased CRF mRNA expression in the central nucleus of the a
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NPC L NPC Niemann Pick
2021-03-23
NPC1L1 (NPC1 [Niemann-Pick C-like-1]-like intracellular cholesterol transporter) is the rate-limiting transmembrane transporter for cholesterol Flubendazole from the intestinal lumen, and it mediates the absorption of both dietary and biliary cholesterol., , NPC1L1 is the target of the cholesterol
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HA activates its receptor channels to cause an inward
2021-03-23
HA activates its receptor channels to cause an inward chloride flux in the insect nervous system (Hardie, 1989). Two genes encoding the subunits of these channels were first identified in D. melanogaster: one previously known as ort (also differently named as hclA, DM-HisCl-α1, hisCl2 and Dm HA-Cl I
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